BPC-157 + TB4-Frag is a combination of the distinct bioactive fragment (Ac-SDKP) of the naturally occurring peptide Thymosin Beta-4 Frag and BPC-157 as BPC-157 arginate with salcaprozate sodium (SNAC) for enhanced absorption.
TB4-Frag (Ac-SDKP)
Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a tetrapeptide from thymosin beta-4 that is made up of the amino acids Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally.
Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*
BPC-157 arginate
BPC-157, a pentadecapeptide composed of 15 amino acids, is often referred to as the "Body Protection Compound." Discovered in the 1970s, this peptide has since become a popular supplement among healthcare providers, recognized for its wide-ranging benefits and impressive results.
BPC-157 capsules offers comprehensive support for gut and digestive health. By promoting healthy gut function, it helps maintain a balanced and efficient digestive system, helping to alleviate common digestive issues. Additionally, BPC-157 supports a healthy inflammatory response with its ability to decrease bloating, swelling, and pain. For these reasons, it stands out over common probiotic products for overall gut health and comfort.
BPC-157 has also been shown to support new cell proliferation. This is essential to the body's ongoing renewal processes. Studies have shown that BPC-157 can promote the healing of muscles, tendons, and ligaments by enhancing fibroblast activity (necessary for new tissue formation) and reducing scarring of the muscle. By increasing regeneration speed of these tissues and reducing scarring, it's possible to significantly improve the recovery process. While still being actively studied for its many benefits, BPC-157 is proving to be a stand out among recovery solutions.
Salcaprozate sodium or SNAC
SNAC is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions. This innovative approach supports optimal absorption for maximum effectiveness.
Peptide Bioavailability
Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies.
Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies.
However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration.
A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally.
The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance.
With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options
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