Performance & Energy

Bundle Contains: 1 BPC-157 (60ct) & 1 TB4-Frag (60ct)   TB4-Frag (Ac-SDKP) Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a tetrapeptide from thymosin beta-4 that is made up of the amino acids Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally. Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*  BPC-157 arginate BPC-157, a pentadecapeptide composed of 15 amino acids, is often referred to as the "Body Protection Compound." Discovered in the 1970s, this peptide has since become a popular supplement among healthcare providers, recognized for its wide-ranging benefits and impressive results.  BPC-157 capsules offers comprehensive support for gut and digestive health. By promoting healthy gut function, it helps maintain a balanced and efficient digestive system, helping to alleviate common digestive issues. Additionally, BPC-157 supports a healthy inflammatory response with its ability to decrease bloating, swelling, and pain. For these reasons, it stands out over common probiotic products for overall gut health and comfort. BPC-157 has also been shown to support new cell proliferation. This is essential to the body's ongoing renewal processes. Studies have shown that BPC-157 can promote the healing of muscles, tendons, and ligaments by enhancing fibroblast activity (necessary for new tissue formation) and reducing scarring of the muscle. By increasing regeneration speed of these tissues and reducing scarring, it's possible to significantly improve the recovery process. While still being actively studied for its many benefits, BPC-157 is proving to be a stand out among recovery solutions. Salcaprozate sodium or SNAC SNAC is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions.  This innovative approach supports optimal absorption for maximum effectiveness. Peptide Bioavailability Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies. Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies. However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration. A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally. The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance. With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options Learn More: BPC-157 product page TB4-Frag product page

BPC-157 + TB4-Frag is a combination of the distinct bioactive fragment (Ac-SDKP) of the naturally occurring peptide Thymosin Beta-4 Frag and BPC-157 as BPC-157 arginate with salcaprozate sodium (SNAC) for enhanced absorption. TB4-Frag (Ac-SDKP) Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a tetrapeptide from thymosin beta-4 that is made up of the amino acids Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally. Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*  BPC-157 arginate BPC-157, a pentadecapeptide composed of 15 amino acids, is often referred to as the "Body Protection Compound." Discovered in the 1970s, this peptide has since become a popular supplement among healthcare providers, recognized for its wide-ranging benefits and impressive results.  BPC-157 capsules offers comprehensive support for gut and digestive health. By promoting healthy gut function, it helps maintain a balanced and efficient digestive system, helping to alleviate common digestive issues. Additionally, BPC-157 supports a healthy inflammatory response with its ability to decrease bloating, swelling, and pain. For these reasons, it stands out over common probiotic products for overall gut health and comfort. BPC-157 has also been shown to support new cell proliferation. This is essential to the body's ongoing renewal processes. Studies have shown that BPC-157 can promote the healing of muscles, tendons, and ligaments by enhancing fibroblast activity (necessary for new tissue formation) and reducing scarring of the muscle. By increasing regeneration speed of these tissues and reducing scarring, it's possible to significantly improve the recovery process. While still being actively studied for its many benefits, BPC-157 is proving to be a stand out among recovery solutions. Salcaprozate sodium or SNAC SNAC is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions.  This innovative approach supports optimal absorption for maximum effectiveness. Peptide Bioavailability Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies. Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies. However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration. A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally. The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance. With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options

As we age, our body's natural collagen production declines, leading to fine lines and wrinkles. Our marine collagen peptides work to replenish collagen levels, promoting stronger hair and nails, improved skin elasticity, and enhanced hydration for a radiant, youthful appearance. This versatile supplement also supports cartilage health and joint mobility, boosts gut health, and aids in muscle recovery and performance, helping you look, feel, and perform at your best every day.

TB4-Frag 500 is a fragment of a naturally occurring peptide called Thymosin Beta-4 (TB4) combined with salcaprozate sodium (SNAC) for enhanced absorption. Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a naturally occurring tetrapeptide from thymosin beta-4 that is made up of the amino acids Ac-Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally. Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*  Salcaprozate sodium, or SNAC, is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions.  This innovative approach supports optimal absorption for maximum effectiveness. Peptide Bioavailability Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies. Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies. However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration. A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally. The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance. With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options

Our BPC-157 delivers 500mcg of BPC-157 in each capsule, offering an effective dose of this powerful peptide. BPC-157, a pentadecapeptide composed of 15 amino acids, is often referred to as the "Body Protection Compound." Discovered in the 1970s, this peptide has since become a popular supplement among healthcare providers, recognized for its wide-ranging benefits and impressive results. Whether you're looking to support recovery, promote healing, or enhance overall wellness, BPC-157 Capsules work to provide a convenient and effective solution. Benefits of BPC-157  BPC-157 capsules offers comprehensive support for gut and digestive health. By promoting healthy gut function, it helps maintain a balanced and efficient digestive system, helping to alleviate common digestive issues. Additionally, BPC-157 supports a healthy inflammatory response with its ability to decrease bloating, swelling, and pain. For these reasons, it stands out over common probiotic products for overall gut health and comfort. BPC-157 has also been shown to support new cell proliferation. This is essential to the body's ongoing renewal processes. Studies have shown that BPC-157 can promote the healing of muscles, tendons, and ligaments by enhancing fibroblast activity (necessary for new tissue formation) and reducing scarring of the muscle. By increasing regeneration speed of these tissues and reducing scarring, it's possible to significantly improve the recovery process. While still being actively studied for its many benefits, BPC-157 is proving to be a stand out among recovery solutions. Resources :1.    Perovic, D., Vukojevic, J., & Zemba Cilic, M. (2019). BPC 157 resolves neuronal damage and prevents memory, locomotor, and coordination deficits. Neurotherapeutics, 17(4), 1990-1995. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504390/2.    Lojo, N., Medvidovic-Grubisic, M., & Drmic, D. (2017). Gastric juice: a unique combination of hydrochloric acid. Journal of Gastroenterology and Hepatology, 35(2), 80-85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928904/3.    Chang, C. H., Tsai, W. C., & Pang, J. H. (2011). Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts. Tendon Research, 23(5), 374-380. https://pubmed.ncbi.nlm.nih.gov/21030672/4.    Sikiric, P., Seiwerth, S., & Cesarec, V. (2017). Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic. Peptides, 67, 14-18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333585/5.    Duzel, A., Vlainic, J., & Seiwerth, S. (2012). Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic. International Journal of Pharmacology, 29(6), 121-126. https://pubmed.ncbi.nlm.nih.gov/22950504/

Recent research has highlighted the potential benefits of NAC + Glycine, which combines N-acetylcysteine (NAC) and glycine, to include: Restoration of Healthy Gluathione Levels: Glutathione levels decline significantly with age, leading to increased oxidative stress and potentially contributing to various age-related health problems Improved Mitochondrial Function: NAC + Glycine supplementation has been shown to improve mitochondrial fatty acid oxidation and correct multiple aspects of mitochondrial dysfunction in older adults, including abnormalities in mitochondrial biogenesis, nutrient sensing, β-oxidation, electron transport chain function, ATP synthesis, and mitophagy Metabolic Health: Aging is also associated with the development of insulin resistance and metabolic dysfunction. NAC + Glycine supplementation has been shown to significantly improve insulin sensitivity and reduce insulin resistance in older adults, as measured by HOMA-IR Reduced Harmful Effects of Oxidative Stress: The ability of NAC + Glycine to improve glutathione status and reduce oxidative stress without inducing reductive stress is a key advantage over other antioxidant supplementation strategies A study from the Baylor College of Medicine suggests that the use of NAC + Glycine supplementation as a promising strategy for promoting healthy aging and improving multiple age-related health outcomes. By addressing key hallmarks of aging, such as glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, and physical decline, NAC + Glycine supplementation may help to prevent or mitigate various age-related diseases and extend healthspan.

Our B-Complex is a high potency blend of the most bioavailable active forms of essential B vitamins for optimal absorption and benefit. While each B vitamin is chemically distinct, they work synergistically in various biochemical functions throughout the body such as supporting cellular energy production and red blood cell formation. *  These bio-active forms also act as coenzymes for the process of detoxification and methylation, processes fundamental for optimal neurological function.* Lifestyle, diet and genetic factors can impact availability and efficacy of nutrient stores throughout the body. B Vitamins are essential for overall health, contributing to multiple functions throughout the system. 5-MTHF - The most bioavailable form of folate - not a synthetic folic acid.Methylcobalamin - The natural and bio-active form of B-12 offers better energy balance, cognitive and cardiovascular support and can benefit the digestive system.Pyridoxal 5'-Phosphate - The active form of B6 that can improve energy, both mental and physical, and may enhance memory and overall cognitive function.Benfotiamine - A form of Thiamine(B1) that has been shown to improve nerve issues associated with neuropathy and diabetes.Niacinimide B-3 - Increases NAD+ levels resulting in more energy and stamina.TMG - Also known as Betaine, Trimethylglycine has been shown to support cardiovascular health and cognitive function.  

Our AMPk Activator formula, formerly "Dihydroberberine", features a highly bioavailable form of dihydroberberine: GlucoVantage®, which has been shown to be up to 5x more bioavailable and 2x longer lasting than regular berberine. AMPk Activator is ideal for people who want an effective nutritional support for glucose balance, healthy lipid metabolism, youth aging and cardiovascular health that is both well-tolerated and convenient.*  ❂ Maintains healthy blood glucose levels and improve insulin sensitivity - Dihydroberberinemaintains healthy blood glucose levels and improves insulin sensitivity by enhancing glucose uptake in cells and reducing insulin resistance, which helps regulate blood sugar effectively. * ❂ Promotes healthy cholesterol & lipid metabolism - by enhancing the activity of enzymes involved in fat metabolism, reducing triglyceride levels, and increasing HDL ("good") cholesterol levels. * ❂ Supports blood vessel health - by improving endothelial function, which enhances the ability of blood vessels to dilate and maintain proper blood flow. It also helps reduce inflammation and oxidative stress, factors that can damage blood vessels. * ❂ Reduces glycation end products (AGEs), thought to contribute to biological aging - by inhibiting the formation of these harmful compounds that result from the reaction between sugars and proteins or fats. By decreasing AGEs, dihydroberberine helps mitigate oxidative stress and inflammation. * ❂ May help increase plasma BHB ketones - by enhancing fatty acid oxidation and promoting the utilization of fats for energy, which encourages the liver to produce more ketones. This can be beneficial for those following ketogenic diets or looking to support metabolic flexibility and energy levels. * ➨ PRO-TIP: Taking dihydroberberine with meals, particularly those that contain carbohydrates, can help optimize its effects on blood sugar regulation - Consider taking it just before or during the meal.   For more information check out the following: 6 Ways to Boost AMPK Activation Dihydroberberine: A Supplement with Significant Impact Across Multiple Systems Nutrigenomic Lean: An exciting new tool to support your body composition, health and longevity goals!!

Rejuvenate UA is a unique blend of research backed ingredients including: Urolithin A Spermidine Ca-AKG ( Calcium Alpha-Ketoglutarate Monohydrate) MitoPrime™ (L-Ergothioneine) This combination was designed to mitigate aging and rejuvenate the body all the way down to the cellular level.* Urolithin A 500 mg Cellular Support: Promotes the function and activity of our mitochondria, the principal organelles responsible cellular energy production and critical for muscle energy metabolism, cell function and performance. By activating pivotal regulatory transcription factors involved in mitochondrial biogenesis, UA can assist in regulating the quantity and quality of mitochondria.  Longevity Enhancement: Promotes mitophagy, the autophagic removal of dysfunctional mitochondria, which is crucial for preventing age-related pathologies. UA activates the PINK1/parkin-dependent mitophagy pathway and other pathways, leading to the degradation of defective mitochondria. This process can mitigate age-related diseases, enhance mitochondrial health, and improve cellular function Neurological Support: May enhance mitochondrial function and improve motor and cognitive functions, supporting brain health. Additionally, it has displayed neuroprotective effects in neurodegenerative disease model studies, including reducing neuroinflammation, preventing the loss of dopaminergic neurons, decreasing α-synuclein aggregation, and inhibiting apoptosis. KEY BENEFITS: Supports cellular health, promotes mitophagy, reduces age-related diseases, offers neuroprotective effects, improves skin health, and more...* Spermidine 3 mg Cellular Support: Results from preclinical studies indicate spermidine supports DNA Stability, cellular growth, and apoptosis.  Longevity Enhancement: Results from preclinical studies indicate higher consumption of spermidine-rich foods correlates with reduced mortality and a life expectancy prolonged by 5 years.  Neurological Support: Results from preclinical studies indicate spermidine assists in the removal of toxic protein aggregates in cells; the cause of dementia and diseases like Parkinson's and Alzheimer's.  KEY BENEFITS: Replenishes depleted levels of Spermidine to inform youthful aging, and increases cellular and immune system health.* Ca-AKG (Calcium Alpha-Ketoglutarate Monohydrate) 1000 mg Antioxidant Support: Results from preclinical studies indicate that Ca-AKG protects against free radical damage related to aging processes and improves blood vessel elasticity in aging organisms.  Longevity Enhancement: Results from preclinical studies indicate Ca-AKG increases the health span of mice by 41% and reduces 31 different signs of age-related frailty. KEY BENEFITS: Decreases inflammation, increases cellular energy, improves training volume and power output in exercise, and improves bio-markers of aging.* MitoPrime™ (L-Ergothioneine) 10 mg Superior Antioxidant Activity: Results from preclinical studies indicate that supplemental L-ergothioneine is up to 30x better than glutathione, and significantly outperforms CoQ10 and Vitamin C.  Oxidative Stress Reduction: Results from preclinical studies indicate that supplemental L-ergothioneine can reduce oxidative stress, which protects mitochondrial function and DNA, and in turn protects against aging.  Restorative:  Results from preclinical studies indicate that supplemental L-ergothioneine can increase natural stores, which decline after age 18. Low levels are associated with suboptimal performance.  KEY BENEFITS: Improves cognitive function, and immune health. Diminishes oxidative stress and accelerates exercise recovery.* Learn more: Spermidine Ca-AKG(Calcium Alpha-Ketoglutarate Monohydrate)    

Our newly upgraded Nutrigenomic Lean (now with Paraxanthine!) is a powerful blend of 6 compounds, each of which effectively support insulin sensitivity and metabolic health in unique ways. (New!) Paraxanthine: Paraxanthine encourages the release of free fatty acids into the bloodstream - fueling endurance and aiding in fat oxidation. This process is supportive for lean body composition and sustained physical output. And unlike caffeine, paraxanthine offers a more focused, smoother experience, making it ideal for those who want clean support for energy, cognition, and metabolism without overstimulation. Andrographolide, the active constituent in andrographis paniculata, has been used for centuries in Ayurveda and Traditional Chinese Medicine. Recent studies have shown that andrographolide can improve glucose uptake and significantly ameliorate insulin resistance as well as oxidative cellular damage.  Dihydroberberine has been shown to be 5x more absorbable and 2x longer lasting(8 hours vs. 4 hours) than regular berberine.  The use of dihydroberberine may improve insulin sensitivity, carbohydrate tolerance and support lean muscle development via AMPK, preferentially driving carbohydrates to muscle rather than fat. DHB is easier on the GI system and is ketogenic-friendly - increasing plasma BHB in the body and reduce inflammatory response level.*  MitoBurn™ L-BAIBA (β-aminoisobutyric Acid) is a patent-pending amino acid  metabolite of L-valine, triggered by the PGC-1a protein from exercising muscles. It has been shown to enhance the body's exercise signal to intensify exercise efforts, promote mitochondrial function and improve cellular energy. L-BAIBA can increase ketones, promote muscle protection, improve cognition and reduce appetite.* Fucoxanthin is a special carotenoid with many bioactivities. The results of animal studies show that fucoxanthin has potential value in preventing and treating lifestyle-related diseases, such as obesity, diabetes, cancer, cardiovascular disease, and other chronic diseases. Fucoxanthin is proved to have no side effects and can be easily extracted from macroalgae and microalgae.* Grains of Paradise, a species of the ginger family, can increases energy expenditure (EE) through the activation of brown adipose tissue. It may also be an effective and safe tool for reducing body fat, mainly by preventing visceral fat accumulation.* For a deeper dive into Tetradecylthioacetic acid, click on the blog link HERE.

  Our Methyl-B12 provides 5mg (5,000 mcg) of vitamin B12 in each very small, pleasant-tasting tablet.  Methylcobalamin, the form of B12 active in the body, appears to be better absorbed and stored in tissues in comparison to cyanocobalamin.* It’s estimated that approximately 40 percent of American’s don’t get enough vitamin B12. Vitamin B12 can be absorbed through the stomach lining typically in the form of animal-based foods.B12 deficiency can contribute to fatigue and brain fog. Benefits to increasing your vitamin B12 intake can include:Healthy digestive system – B12 can support gut health and the cardiovascular system.* Better energy balance – Because your body needs B12 to convert carbohydrates into glucose, it can improve your overall energy and diminish fatigue.* Cognitive support – Vitamin B12 helps in the production of DNA and can support your nervous system and stress resiliency.*

Backed by many successful clinical trials, years of research and the leading team in Nitric Oxide research, this proprietary, clinical strength and patented Neo40 Professional formula is developed out of years of scientific research from the University of Texas Health Science Center and the N-O Discovery Program. Because this clinical-strength formula is biphasic, it allows for the conversion of Nitrate to Nitrite and then to N-O over time in the endothelium as needed. It is the most efficacious, concentrated and convenient daily supplement to help to quickly increase the body’s Nitric Oxide levels. Neo40 Professional offers significantly more N-O production with each tablet than the flagship Neo40 Daily, with added methylfolate. This is critical for those patients who have a methyl tetrahydrofolate reductase genetic variant (referred to as the MTHFR SNP) as well as SNPs in the Nitric Oxide Synthase (NOS) gene. People with MTHFR SNP are unable to maintain enough reduced tetrahydrobiopterin to support endogenous Nitric Oxide production. The addition of methylfolate can help overcome this genetic problem.   Consult your physician prior to taking Neo40 Professional if you’re taking 1) organic nitrate medications such as nitroglycerin or isosorbide, 2) erectile dysfunction drugs, since the combination of the two may cause an unsafe drop in blood pressure, 3) blood thinner medications, or 4) medications related to lowering blood pressure. Discontinue use and contact your physician if you experience dizziness or fainting.