❂ Enhances Tissue Repair*
❂ Balances Inflammatory Processes*
❂ Supports Joint and Muscle Health*
❂ Repairs & Protects Cardiovascular System*
❂ Protects Cognitive Health*
❂ Modulates Immune Response*
❂ Improves Skin Health*
TB4 (Thymosin Beta Active Fragment)
SNAC (salcaprozate soldium)
inactive ingredients: Delayed release vegetable capsules (hypromellose, gellan gum), microcrystalline cellulose, silicon dioxide, organic carnauba wax
Formulated to Exclude: Dairy or animal products, gluten, egg, soy, shellfish, fish, peanuts, tree nuts, wheat, ingredients derived from genetically modified organisms (GMOs), artificial colors, flavors and preservatives.
What is TB4-Frag? TB4-Frag is a bioactive fragment derived from thymosin beta-4 (TB4), a naturally occurring peptide in the body. It is designed to provide the regenerative and immune-modulating benefits of full-length TB4 in a more potent and targeted form.
What are the benefits of TB4-Frag? TB4-Frag can support tissue repair, promote immune system balance, reduce inflammation, and can enhance gut health. It may also play a role in addressing fibrosis, improving skin health, and supporting overall recovery processes.
What are the differences between Elementals' TB4-Frag, TB4 and TB-500? There are many similarities in the benefit profile of TB4 and its derivatives and as awareness of this peptide grows, you may find some companies interchanging the names. That is why it is best to identify the product by its specific amino acid sequence, as this will help you to ascertain its unique benefits and best delivery method.
Both TB-500 and TB4-Frag are derived from the full peptide: TB4 or Thymosin Beta 4. TB4 Fragment: SDKP or Ac-SDKP, is a modified form of the peptide TB4- It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally.
Why should I choose Elementals' TB4-Frag over other TB4 Frag products? TB4-Frag is more potent than full-length TB4, providing similar or greater benefits at a lower dosage. Its targeted action makes it particularly effective for supporting regeneration and inflammation reduction. Our Thymosin Beta 4 fragment includes SNAC, to maximize absorption and is delivered in delayed release capsules to ensure stability. It is manufactured in a cGMP-certified facility for quality and purity.
Should I take this on an empty stomach or with food? Typically, peptides are better absorbed when taken on an empty stomach. However, our TB4-Frag uses delayed release capsules, designed to bypass the stomach and slowly release in the small intestine. As a result, our TB4-Frag can be taken with or without food.
What other supplements should I pair TB4-Frag with? Stacking any of the following can be beneficial depending on your health goals: BPC-157 can work synergistically on healing and tissue repair, Collagen (type I&III) is vital for supporting connective tissue, including tendons, ligaments an skin, and Vitamin C is crucial for collagen synthesis and tissue repair. Curcumin could enhance healing and modulate inflammation, Magnesium supports muscle function and repair while reducing cramping and encouraging relaxation, and Omega 3's like DHA and EPA can offer potent inflammation relief and support overall recovery.
Are there any side effects associated with TB4-Frag? What should I consider before taking? TB4-Frag is generally considered safe when used as directed. It is well-tolerated, but individuals should consult a healthcare professional, especially if pregnant, nursing, or taking other medications. Discontinue use if adverse reactions occur. Always store capsules in a cool, dry place.
How long does it take to experience the benefits of TB4-Frag? The time needed to experience the benefits of TB4-Frag varies by individual. Many people will typically notice improvements only after 6-8 weeks. Regular supplementation is key to achieving long-term benefits.
Do I need a prescription for TB4-Frag? No prescription is required for oral TB4-Frag as it is sold as an over-the-counter dietary supplement.
Who should consider using TB4-Frag? Individuals looking to support healing from injuries, reduce chronic inflammation, boost immune health, or address conditions related to gut health and tissue repair may benefit from TB4-Frag. It’s also useful for athletes and active individuals seeking enhanced recovery.
What is the difference between oral and injectable TB4 products? Oral capsules are more convenient and less invasive. Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies. Our TB4-Frag uses the advanced delivery technology of SNAC and delayed release capsules to support absorption through the digestive system.
Can TB4-Frag help with athletic recovery? Yes, TB4-Frag can support muscle and tissue repair, reduce inflammation, and promote faster recovery, making it an excellent option for athletes or active individuals.
How does TB4-Frag work? TB4-Frag enhances cellular repair and regeneration by interacting with actin, a protein critical for cell movement and healing. It also modulates inflammatory responses and supports tissue integrity, making it beneficial for recovery and resilience.
Is this product third-party tested? Our TB4-Frag is tested by a third-party laboratory for purity, potency, and authenticity.
Where is this product manufactured and what product quality control tests are performed? Our TB4-Frag is manufactured in Nevada in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.
TB4-Frag 500 is a fragment of a naturally occurring peptide called Thymosin Beta-4 (TB4) combined with salcaprozate sodium (SNAC) for enhanced absorption.
Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a naturally occurring tetrapeptide from thymosin beta-4 that is made up of the amino acids Ac-Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally.
Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*
Salcaprozate sodium, or SNAC, is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions. This innovative approach supports optimal absorption for maximum effectiveness.
Peptide Bioavailability
Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies.
Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies.
However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration.
A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally.
The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance.
With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options
