Wholesale: Rejuvenate UA
$1,560.00
Case of 24 bottles of Rejuvenate UA
This product is only available for purchase by approved Apeiron Elementals Wholesale clients.
Minimum order = 1 case (24 bottles).
Wholesale pricing is subject to change at the discretion of Apeiron Elementals, LLC.
*MAP = Minimum Advertised Price for this product is: $149 per bottle.
All prices shown do NOT include shipping charges. Cost of shipping varies based on weight, package size and destination, and will be calculated for you at checkout.
90 Capsules (30 servings) 30-Day Supply
Suggested use: As a dietary supplement, take three capsules daily.
Rejuvenate UA is a unique blend of research backed ingredients including:
Urolithin A
Spermidine
Ca-AKG ( Calcium Alpha-Ketoglutarate Monohydrate)
MitoPrime™ (L-Ergothioneine)
This combination was designed to mitigate aging and rejuvenate the body all the way down to the cellular level.*
Urolithin A 500 mg
Cellular Support: Promotes the function and activity of our mitochondria, the principal organelles responsible cellular energy production and critical for muscle energy metabolism, cell function and performance. By activating pivotal regulatory transcription factors involved in mitochondrial biogenesis, UA can assist in regulating the quantity and quality of mitochondria.
Longevity Enhancement: Promotes mitophagy, the autophagic removal of dysfunctional mitochondria, which is crucial for preventing age-related pathologies. UA activates the PINK1/parkin-dependent mitophagy pathway and other pathways, leading to the degradation of defective mitochondria. This process can mitigate age-related diseases, enhance mitochondrial health, and improve cellular function
Neurological Support: May enhance mitochondrial function and improve motor and cognitive functions, supporting brain health. Additionally, it has displayed neuroprotective effects in neurodegenerative disease model studies, including reducing neuroinflammation, preventing the loss of dopaminergic neurons, decreasing α-synuclein aggregation, and inhibiting apoptosis.
KEY BENEFITS: Supports cellular health, promotes mitophagy, reduces age-related diseases, offers neuroprotective effects, improves skin health, and more...*
Spermidine 3 mg
Cellular Support: Results from preclinical studies indicate spermidine supports DNA Stability, cellular growth, and apoptosis.
Longevity Enhancement: Results from preclinical studies indicate higher consumption of spermidine-rich foods correlates with reduced mortality and a life expectancy prolonged by 5 years.
Neurological Support: Results from preclinical studies indicate spermidine assists in the removal of toxic protein aggregates in cells; the cause of dementia and diseases like Parkinson's and Alzheimer's.
KEY BENEFITS: Replenishes depleted levels of Spermidine to inform youthful aging, and increases cellular and immune system health.*
Ca-AKG (Calcium Alpha-Ketoglutarate Monohydrate) 1000 mg
Antioxidant Support: Results from preclinical studies indicate that Ca-AKG protects against free radical damage related to aging processes and improves blood vessel elasticity in aging organisms.
Longevity Enhancement: Results from preclinical studies indicate Ca-AKG increases the health span of mice by 41% and reduces 31 different signs of age-related frailty.
KEY BENEFITS: Decreases inflammation, increases cellular energy, improves training volume and power output in exercise, and improves bio-markers of aging.*
MitoPrime™ (L-Ergothioneine) 10 mg
Superior Antioxidant Activity: Results from preclinical studies indicate that supplemental L-ergothioneine is up to 30x better than glutathione, and significantly outperforms CoQ10 and Vitamin C.
Oxidative Stress Reduction: Results from preclinical studies indicate that supplemental L-ergothioneine can reduce oxidative stress, which protects mitochondrial function and DNA, and in turn protects against aging.
Restorative: Results from preclinical studies indicate that supplemental L-ergothioneine can increase natural stores, which decline after age 18. Low levels are associated with suboptimal performance.
KEY BENEFITS: Improves cognitive function, and immune health. Diminishes oxidative stress and accelerates exercise recovery.*
Learn more:
Spermidine
Ca-AKG(Calcium Alpha-Ketoglutarate Monohydrate)
Wholesale: Senolytic Formula
$936.00
Case of 24 bottles of Senolytic Formula
This product is only available for purchase by approved Apeiron Elementals Wholesale clients.
Minimum order = 1 case (24 bottles).
Wholesale pricing is subject to change at the discretion of Apeiron Elementals, LLC.
*MAP = Minimum Advertised Price for this product is: $59 per bottle.
All prices shown do NOT include shipping charges. Cost of shipping varies based on weight, package size and destination, and will be calculated for you at checkout.
NEW IMPROVED FORMULA!
Senolytic Formula
Wondering how you can help rid your body of senescent cells (aka zombie cells) that may build up due to stressors or simple aging? Curious if it is possible to prevent their formation? While many diet and lifestyle factors can reduce potential cell damage and enhance your own immune system’s natural "killer cell" activity, senolytic compounds are the most targeted and direct solution, and a vital component to a thriving body as you age.*
Cellular senescence is a natural part of the aging process and is often defined as a process by which a cell ages and permanently stops dividing but does not die. Instead of experiencing apoptosis (programed cell death), these cells remain, build up and begin to negatively affect surrounding cells via secreted pro-inflammatory factors including cytokines, immune modulators, growth factors and proteases. Senolytic compounds selectively target senescent cells.
Our formula contains the following natural senolytic compounds:
Quercetin
Fisetin 98%
Cordyceps 30% polysaccharides
Curcumin Extract 95%
Resveratrol (std. to 50% trans-resveratrol)
Green Tea Extract/EGCG
Wholesale: TB4-Frag 500
$1,344.00
Case of 24 bottles of TB4-Frag 500
This product only available for purchase by approved Apeiron Elementals Wholesale clients.
Minimum order = 1 case (24 bottles).
Wholesale pricing is subject to change at the discretion of Apeiron Elementals, LLC.
*MAP = Minimum Advertised Price for this product is: $120 per bottle.
All prices shown do NOT include shipping charges. Cost of shipping varies based on weight, package size and destination, and will be calculated for you at checkout.
TB4-Frag 500 is a fragment of a naturally occurring peptide called Thymosin Beta-4 (TB4) combined with salcaprozate sodium (SNAC) for enhanced absorption.
Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a naturally occurring tetrapeptide from thymosin beta-4 that is made up of the amino acids Ac-Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally.
Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging,
and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*
Salcaprozate sodium, or SNAC, is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions. This innovative approach supports optimal absorption for maximum effectiveness.
Peptide Bioavailability
Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies.
Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies.
However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration.
A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally.
The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance.
With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options
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