DHH-B: Nature's Answer to Stress, Sleep and Well-being


In our busy lives, it often feels like stress can be found at every turn. While some stress can offer motivation, an excessive amount can affect our sense of balance and peace.

Picture your body as a guardian, peaceful, but ready to jump into action in response to challenges or stressors it encounters. Ideally, once these challenges ease, your body would naturally find its equilibrium again. However, faced with a consistent stream of stressors – whether physical, mental, or emotional, your body might remain in a heightened state of awareness. This prolonged stress can lead to challenges like reduced concentration, fluctuating moods, feelings of exhaustion, and various mental and physical strains.

Moreover, chronic stress has connections to health issues such as heart concerns, high blood pressure, diabetes, and emotional well-being challenges like feelings of sadness or worry.

As we look at lifestyle modifications and natural remedies to improve our resilience, one compound has emerged as a frontrunner for its remarkable therapeutic potential: Dihydrohonokiol-B (DHH-B)

Derived from the bark of magnolia officinalis, this natural compound is being celebrated for its multifaceted benefits. Let's dive deeper into the world of DHH-B and discover its transformative impact on our health.

Honokiol or Dihydrohonikiol-B

While you may be familiar with magnolia bark or honokiol, DHH-B (Dihydrohonokiol-B), a variant of honokiol derived from magnolia bark, is 20x stronger! Making waves in the world of natural supplements, DHH-B is being recommended for its ability to induce tranquility, alleviate stress, promote restful sleep, and support cognitive function and health. In short, DHH-B is redefining holistic health solutions.

Impact on GABA and Other Neurotransmitters

At the heart of DHH-B's therapeutic benefit lies its unique interaction with neurotransmitters. The compound shines in its GABAergic modulation, acting as a positive allosteric modulator of gamma-aminobutyric acid (GABA) receptors. This enhancement amplifies GABAergic neurotransmission, promoting relaxation and a sense of calmness. 

DHH-B also influences the release and reuptake of additional neurotransmitters including dopamine, serotonin, and norepinephrine. By modulating the release and reuptake of these neurotransmitters, DHH-B paves the way for enhanced mood, relaxation, and cognitive function.

Antioxidant and Inflammation Support

Beyond neurotransmitter modulation, DHH-B showcases robust antioxidant and anti-inflammatory properties. It scavenges reactive oxygen species (ROS) and upregulates endogenous antioxidant enzymes, contributing to both short-term and long-term brain health. 

In addition to DHH-B’s neuroprotective and anti-aging effects, its ability to support a health inflammatory response underscores its potential in promoting joint health, digestive well-being, and immune system functionality.


Who can benefit from DHH-B?

Those looking for:

  • More restorative sleep 
  • Better stress resilience
  • Enhanced mood
  • Improved mental clarity and focus
  • Effective inflammatory response
  • Protection from oxidative stress 

DHH-B, derived from the traditional Chinese medicinal plant magnolia officinalis, offers a natural alternative to many pharmaceutical protocols like benzodiazepines and others. With its multifaceted benefits spanning stress relief, enhanced sleep, mood regulation, cognitive support, and antioxidant properties, DHH-B is paving the way for a holistic approach to health and well-being. 



Lin Y, et al. "Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update." Front Pharmacol. 2021.

Shen JL, et al. "Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders." Molecules. 2010.

Hou Y, et al. "Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice." Neuropharmacology. 2010.

Woo SM, et al. "Honokiol Enhances TRAIL-Mediated Apoptosis through STAMBPL1-Induced Survivin and c-FLIP Degradation." Biomolecules. 2019.

Arora S, et al. "Honokiol: a novel natural agent for cancer prevention and therapy." Curr Mol Med. 2012.



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