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Cellular senescence is a natural part of the aging process and is often defined as a process by which a cell ages and permanently stops dividing but does not die. Instead of experiencing apoptosis (programed cell death), these cells remain, build up and begin to negatively affect surrounding cells via secreted pro-inflammatory factors including cytokines, immune modulators, growth factors and proteases. Senolytic compounds selectively target senescent cells. Wondering how you can help rid your body of senescent cells (aka zombie cells) that may build up due to stressors or simple aging? Curious if it is possible to prevent their formation? While many diet and lifestyle factors can reduce potential cell damage and enhance your own immune system’s natural "killer cell" activity, senolytic compounds are the most targeted and direct solution, and a vital component to a thriving body as you age.*  Fisetin is found in fruits like strawberries and apples. It has been shown to reduce oxidative stress and inflammation, enhance brain function, and extend lifespan in animal studies. Its senolytic activity helps clear senescent cells, potentially improving tissue function and resilience to age-related decline. Quercetin, present in foods like onions and berries, also exhibits strong anti-inflammatory and antioxidant properties. As a senolytic, quercetin can aid in removing senescent cells, as a result, it supports better cardiovascular health, reduces frailty, and potentially enhances overall longevity. Olive leaf extract (with 20% oleuropein) is rich in polyphenols, which possess strong antioxidant and anti-inflammatory properties. Oleuropein has been shown to protect cardiovascular health, support immune function, and potentially enhance metabolic health, contributing to overall vitality. Trans-resveratrol, a compound found in red grapes and berries, is renowned for its longevity-promoting effects. It activates certain pathways related to cellular health and stress resistance, enhancing cardiovascular health, reducing inflammation, and potentially extending lifespan by mimicking the effects of calorie restriction. Green tea extract, standardized to 50% EGCG and 90% polyphenols, is a powerhouse of antioxidants. EGCG (epigallocatechin gallate) is particularly effective in reducing oxidative stress, supporting brain health, and enhancing metabolic rate. Its polyphenols also contribute to anti-inflammatory effects and may help reduce the risk of chronic diseases.

Magnesium Threonate Powder features magnesium L-threonate (as Magtein®), the only form of magnesium known to cross the blood-brain barrier.                        Complemented by highly absorbable Albion® di-magnesium malate and TRAACS® magnesium lysinate glycinate chelate, this formula is designed to boost the brain’s magnesium level. Magnesium is vital to supporting brain health and promoting healthy nervous system functions.*                                   

  Our Methyl-B12 provides 5mg (5,000 mcg) of vitamin B12 in each very small, pleasant-tasting tablet.  Methylcobalamin, the form of B12 active in the body, appears to be better absorbed and stored in tissues in comparison to cyanocobalamin.* It’s estimated that approximately 40 percent of American’s don’t get enough vitamin B12. Vitamin B12 can be absorbed through the stomach lining typically in the form of animal-based foods.B12 deficiency can contribute to fatigue and brain fog. Benefits to increasing your vitamin B12 intake can include:Healthy digestive system – B12 can support gut health and the cardiovascular system.* Better energy balance – Because your body needs B12 to convert carbohydrates into glucose, it can improve your overall energy and diminish fatigue.* Cognitive support – Vitamin B12 helps in the production of DNA and can support your nervous system and stress resiliency.*

TB4-Frag 500 is a fragment of a naturally occurring peptide called Thymosin Beta-4 (TB4) combined with salcaprozate sodium (SNAC) for enhanced absorption. Thymosin Beta-4 Frag(1-4) (Ac-SDKP) is a naturally occurring tetrapeptide from thymosin beta-4 that is made up of the amino acids Ac-Ser-Asp-Lys-Pro. It is a shorter fragment of the original peptide, which has been found to have better oral bioavailability and approximately 10 times more potent by weight compared to the full-length peptide. This is due to its smaller size and modified structure, which allows it to be more easily absorbed by the body when taken orally. Research underscores its regenerative properties, ability to modulate the immune system, address inflammaging, and its supportive roles in gut health, cardiovascular health and reducing kidney/liver fibrosis.* It may even inform a more natural approach for high blood pressure due to its association with angiotensin-converting enzyme.*  Salcaprozate sodium, or SNAC, is a cutting-edge ingredient created to promote intestinal permeation. It was originally developed for improving the oral delivery of macromolecules. Clinical research demonstrates SNAC's ability to significantly enhance absorption, increasing peptide uptake by up to nine times without disrupting the integrity of intestinal tight junctions.  This innovative approach supports optimal absorption for maximum effectiveness. Peptide Bioavailability Peptides are short chains of amino acids that are being extensively researched for their potential therapeutic benefits. While they are commonly associated with subcutaneous (SubQ) Administration, recent advancements in peptide modification have allowed for better oral bioavailability. In fact, many peptides can now be taken orally in pill or capsule form, making them more convenient and accessible to a wider range of research and clinical studies. Thymosin Beta 4 is a peptide with a wide range of potential therapeutic benefits. It has been shown to promote wound healing, reduce inflammation, and stimulate tissue repair in numerous animal studies. However, in its original form, TB4 had to be administration subcutaneously to be effective. Thymosin Beta4 Fragment SDKP is a modified form of TB4 and TB500 that has been shown to have better oral bioavailability, allowing it to be effective when taken orally rather than via SubQ administration. A study published in the Journal of Chromatography B demonstrated that Thymosin Beta4 Fragment SDKP had approximately 30% oral bioavailability in rats, which is significantly higher than the less than 1% bioavailability observed with TB500. Another study published in the Journal of Peptide Science showed that Thymosin Beta4 Fragment SDKP had a longer half-life and a greater area under the curve (AUC) than TB500 when taken orally in rats. These findings provide strong scientific evidence that modifications to peptide sequences, such as fragmenting longer sequences, can significantly improve their bioavailability and effectiveness when taken orally. The development of oral availability is an exciting advancement in the field of peptide therapeutics. While subQ administrations have been the primary mode of administration for many peptides, recent research has shown that modifying the salt form of a peptide like BPC-157, can improve its oral bioavailability, making it a viable alternative to injections. This offers numerous benefits, including greater convenience, reduced pain and discomfort, and improved compliance. With ongoing research and development, it is likely that we will continue to see progress in the field of orally available peptides, providing new treatment options

Our AMPk Activator formula, formerly "Dihydroberberine", features a highly bioavailable form of dihydroberberine: GlucoVantage®, which has been shown to be up to 5x more bioavailable and 2x longer lasting than regular berberine. AMPk Activator is ideal for men and women who want an effective nutritional therapy for glucose balance, lipid metabolism and cardiovascular health that is both well-tolerated and convenient.*  For more information check out the following: 6 Ways to Boost AMPK Activation Dihydroberberine: A Supplement with Significant Impact Across Multiple Systems Nutrigenomic Lean: An exciting new tool to support your body composition, health and longevity goals!!

DHEA is a natural steroid hormone that is synthesized from cholesterol through pregnenelone by the adrenal glands. DHEA acts as an antagonist for glucocorticosteroid hormones and is the parent precursor for other important steroid hormones, such as estradiol and other estrogens, and testosterone. While not a precursor to progesterone, DHEA can indirectly influence progesterone synthesis through a feedback mechanism whereby pregnenelone is converted to progesterone based on DHEA levels. DHEA levels drop approximately 10% per decade after age 25.  *Please see the DHEA International Shipping information, regarding countries that do NOT allow import of DHEA. Please check the list prior to placing your order, if you are outside of the U.S.

DIM Formula is an ideal combination of DIM (diindolylmethane) and truebroc™ (glucoraphanin) that helps protect estrogen-sensitive tissues by promoting healthy estrogen metabolism and supporting detoxification and neutralization of harmful estrogen metabolites and xenoestrogens.*

Recent research has highlighted the potential benefits of NAC + Glycine, which combines N-acetylcysteine (NAC) and glycine, to include: Restoration of Healthy Gluathione Levels: Glutathione levels decline significantly with age, leading to increased oxidative stress and potentially contributing to various age-related health problems Improved Mitochondrial Function: NAC + Glycine supplementation has been shown to improve mitochondrial fatty acid oxidation and correct multiple aspects of mitochondrial dysfunction in older adults, including abnormalities in mitochondrial biogenesis, nutrient sensing, β-oxidation, electron transport chain function, ATP synthesis, and mitophagy Metabolic Health: Aging is also associated with the development of insulin resistance and metabolic dysfunction. NAC + Glycine supplementation has been shown to significantly improve insulin sensitivity and reduce insulin resistance in older adults, as measured by HOMA-IR Reduced Harmful Effects of Oxidative Stress: The ability of NAC + Glycine to improve glutathione status and reduce oxidative stress without inducing reductive stress is a key advantage over other antioxidant supplementation strategies A study from the Baylor College of Medicine suggests that the use of NAC + Glycine supplementation as a promising strategy for promoting healthy aging and improving multiple age-related health outcomes. By addressing key hallmarks of aging, such as glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, and physical decline, NAC + Glycine supplementation may help to prevent or mitigate various age-related diseases and extend healthspan.

Algae DHA contains docosahexaenoic acid (DHA), a conditionally essential omega-3 fatty acid.DHA is highly concentrated in brain synaptosomes, the cerebral cortex, mitochondria, and retina. It plays an important role in the fluidity and permeability of cell membranes and cellular communication and supports optimal function of the brain, eyes, and immune system.This patented form of DHA is derived from marine algae.  

Our B-Complex is a high potency blend of the most bioavailable active forms of essential B vitamins for optimal absorption and benefit. While each B vitamin is chemically distinct, they work synergistically in various biochemical functions throughout the body such as supporting cellular energy production and red blood cell formation. *  These bio-active forms also act as coenzymes for the process of detoxification and methylation, processes fundamental for optimal neurological function.* Lifestyle, diet and genetic factors can impact availability and efficacy of nutrient stores throughout the body. B Vitamins are essential for overall health, contributing to multiple functions throughout the system. 5-MTHF - The most bioavailable form of folate - not a synthetic folic acid.Methylcobalamin - The natural and bio-active form of B-12 offers better energy balance, cognitive and cardiovascular support and can benefit the digestive system.Pyridoxal 5'-Phosphate - The active form of B6 that can improve energy, both mental and physical, and may enhance memory and overall cognitive function.Benfotiamine - A form of Thiamine(B1) that has been shown to improve nerve issues associated with neuropathy and diabetes.Niacinimide B-3 - Increases NAD+ levels resulting in more energy and stamina.TMG - Also known as Betaine, Trimethylglycine has been shown to support cardiovascular health and cognitive function.  

Histamine Support is a patented enzyme formula containing diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. Histamine Support does not manage or address antibody-related or IgE-related food allergies.