Apeiron Elementals Brand

Melatonin is produced naturally in the pineal gland of the brain in response to changes in light exposure; it helps maintain healthy sleep patterns as well as antioxidant and immune activities. Melatonin can be taken as a supplement to support these functions by promoting normal levels of melatonin in the body.

The Apeiron Elementals Foundational Bundle includes: Foundational Multivitamin 120ct  D3 + K2 60ct  High potency EPA/DHA 120ct -Foundational Multivitamin Foundation Nutrition for a Variety of Protocols Basic “Insurance” Formula for Wellness Supports Antioxidant Protection Supports Detoxification Supports Individuals with Stressful Lifestyles This formulation is the best that we have found for all-around health. The forms of the vitamins & minerals, as well as the amounts, supports a healthy balance for the majority of people. Take two capsules twice daily, or as directed by your healthcare practitioner.  This high-quality, hypoallergenic, multivitamin/mineral blend includes activated vitamins; folate as Quatrefolic® (5-MTHF) for optimal utilization; and patented Albion TRAACS® chelated mineral complexes in vegetarian capsules. The comprehensive nutrient profile in Foundation Multivitamin supports foundational wellness; antioxidant activity with vitamins C and E, selenium, and beta-carotene; and phase I detoxification. Click here for detailed product information PDF - Product Brochure -D3K2  Supports Bone Health by Promoting Carboxylation of Bone Proteins Supports Cardiovascular Health by Affecting Arterial Calcium Deposits Supports Healthy Blood Clotting D3 is involved in over 160 metabolic processes in the body K2 Vitamin D3 5000 provides not only an optimal level of Vitamin D3 but also Vitamin K2 as menaquinone-7 (MK-7), a highly bioavailable and bioactive form of K2. Historical use and numerous studies have demonstrated the efficacy of vitamin K supplements for bone and cardiovascular health. Click here for product information PDF - Product Brochure -Omegas (high potency EPA/DHA)  Affects the Production of Arachidonic Acid-Derived Eicosanoids Helps the Body Generate Specialized Proresolving Lipid Mediators Supports Cardiovascular Health Supports Healthy Mental Functioning Supports Healthy Glucose and Insulin Metabolism High potency EPA/DHA contains concentrated Norwegian fish oil that provides 900 mg of EPA and DHA omega-3 fatty acids in triglyceride form. To assure maximum purity and freshness, the oil is stabilized with vitamin E (as d-alpha tocopherol). EPA and DHA from fish oil have been extensively researched for their health benefits. They promote wellness by supporting cardiovascular health, normal platelet aggregation, cytokine balance, joint health, and brain and nervous system function. Contaminants: Heavy metals and persistent organic pollutants (POPs), such as dioxins, dichlorodiphenyltrichloroethane (DDT), polychlorinated biphenyls (PCBs), and brominated flame retardants (BFRs) accumulate in the marine food chain. Proprietary manufacturing procedures, including triple distillation or stripping of the starter oil, reduce these aforementioned contaminants and other POPs to extremely low levels. Every batch is controlled to be less than half of the limits set in the current guidelines (e.g., European Pharmacopoeia, Global Organization for EPA and DHA (GOED), United States Pharmacopeia), and actual POP levels typically show values close to or below detection limits. Oxidation: Fish oil is highly susceptible to oxidation. If the oil becomes oxidized during processing, the oil’s health benefits may be diminished. Closed production under nitrogen or low pressure from first refining to finished drumming ensures low oxidation, which is indicated by anisidine values that fall well below other oils on the market. Every batch is tested for oxidation products before release. Click here for detailed product information PDF - Product Brochure  

The Apeiron Elementals Longevity Duo Bundle includes: NAC + Glycine Rejuvenate UA w/ Urolithin A   Both NAC + Glycine and Rejuvenate UA promote: ➕Mitochondrial Health and Function ➕Cellular Health ➕Positive Impacts on Bio-Markers and Hallmarks of Aging ➕Metabolic Health ➕Diminished Oxidative Stress Plus:     ⚡NAC + Glycine Supports & Replenishes Optimal Glutathione Levels ⚡Rejuvenate UA Improves Skin Health, Immune Function and Supports Healthy Inflammatory and Neuroinflammatory Processes These formulas work synergistically to help build a comprehensive longevity stack. Add our Senolytic Formula for a truly optimal healthy aging regimen!   🌟 🌟Our formulas are physician formulated and used in clinic 🌟 🌟  For a deeper dive into the individual products and how they work see below...   NAC + Glycine Promotes healthy aging/positively impacts hallmarks of aging Supports mitochondrial function Provides oxidative stress relief Restores glutathione levels Improves metabolic health Recent research has highlighted the potential benefits of NAC + Glycine, which combines N-acetylcysteine (NAC) and glycine, to include: Restoration of Healthy Gluathione Levels: Glutathione levels decline significantly with age, leading to increased oxidative stress and potentially contributing to various age-related health problems Improved Mitochondrial Function: NAC + Glycine supplementation has been shown to improve mitochondrial fatty acid oxidation and correct multiple aspects of mitochondrial dysfunction in older adults, including abnormalities in mitochondrial biogenesis, nutrient sensing, β-oxidation, electron transport chain function, ATP synthesis, and mitophagy Metabolic Health: Aging is also associated with the development of insulin resistance and metabolic dysfunction. NAC + Glycine supplementation has been shown to significantly improve insulin sensitivity and reduce insulin resistance in older adults, as measured by HOMA-IR Reduced Harmful Effects of Oxidative Stress: The ability of NAC + Glycine to improve glutathione status and reduce oxidative stress without inducing reductive stress is a key advantage over other antioxidant supplementation strategies A study from the Baylor College of Medicine suggests that the use of NAC + Glycine supplementation as a promising strategy for promoting healthy aging and improving multiple age-related health outcomes. By addressing key hallmarks of aging, such as glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, and physical decline, NAC + Glycine supplementation may help to prevent or mitigate various age-related diseases and extend healthspan.   Rejuvenate UA Informs youthful aging Promotes mitophagy Improves cellular health & bio-markers of aging Supports healthy immune function Accelerates exercise recovery Supports healthy inflammatory and neuroinflammatory processes Diminishes oxidative stress Improves skin health A unique blend of research backed ingredients including: Urolithin A Spermidine Ca-AKG ( Calcium Alpha-Ketoglutarate Monohydrate) MitoPrime™ (L-Ergothioneine) This combination was designed to mitigate aging and rejuvenate the body all the way down to the cellular level.* Urolithin A 500 mg Cellular Support: Promotes the function and activity of our mitochondria, the principal organelles responsible cellular energy production and critical for muscle energy metabolism, cell function and performance. By activating pivotal regulatory transcription factors involved in mitochondrial biogenesis, UA can assist in regulating the quantity and quality of mitochondria.  Longevity Enhancement: Promotes mitophagy, the autophagic removal of dysfunctional mitochondria, which is crucial for preventing age-related pathologies. UA activates the PINK1/parkin-dependent mitophagy pathway and other pathways, leading to the degradation of defective mitochondria. This process can mitigate age-related diseases, enhance mitochondrial health, and improve cellular function Neurological Support: May enhance mitochondrial function and improve motor and cognitive functions, supporting brain health. Additionally, it has displayed neuroprotective effects in neurodegenerative disease model studies, including reducing neuroinflammation, preventing the loss of dopaminergic neurons, decreasing α-synuclein aggregation, and inhibiting apoptosis. KEY BENEFITS: Supports cellular health, promotes mitophagy, reduces age-related diseases, offers neuroprotective effects, improves skin health, and more...* Spermidine 3 mg Cellular Support: Results from preclinical studies indicate spermidine supports DNA Stability, cellular growth, and apoptosis.  Longevity Enhancement: Results from preclinical studies indicate higher consumption of spermidine-rich foods correlates with reduced mortality and a life expectancy prolonged by 5 years.  Neurological Support: Results from preclinical studies indicate spermidine assists in the removal of toxic protein aggregates in cells; the cause of dementia and diseases like Parkinson's and Alzheimer's.  KEY BENEFITS: Replenishes depleted levels of Spermidine to inform youthful aging, and increases cellular and immune system health.* Ca-AKG (Calcium Alpha-Ketoglutarate Monohydrate) 1000 mg Antioxidant Support: Results from preclinical studies indicate that Ca-AKG protects against free radical damage related to aging processes and improves blood vessel elasticity in aging organisms.  Longevity Enhancement: Results from preclinical studies indicate Ca-AKG increases the health span of mice by 41% and reduces 31 different signs of age-related frailty. KEY BENEFITS: Decreases inflammation, increases cellular energy, improves training volume and power output in exercise, and improves bio-markers of aging.* MitoPrime™ (L-Ergothioneine) 10 mg Superior Antioxidant Activity: Results from preclinical studies indicate that supplemental L-ergothioneine is up to 30x better than glutathione, and significantly outperforms CoQ10 and Vitamin C.  Oxidative Stress Reduction: Results from preclinical studies indicate that supplemental L-ergothioneine can reduce oxidative stress, which protects mitochondrial function and DNA, and in turn protects against aging.  Restorative:  Results from preclinical studies indicate that supplemental L-ergothioneine can increase natural stores, which decline after age 18. Low levels are associated with suboptimal performance.  KEY BENEFITS: Improves cognitive function, and immune health. Diminishes oxidative stress and accelerates exercise recovery.* Learn more: Spermidine Ca-AKG(Calcium Alpha-Ketoglutarate Monohydrate)

The Apeiron Elementals Longevity Trio bundle includes: NAC + Glycine Rejuvenate UA w/ Urolithin A Senolytic Formula   Our NAC + Glycine and Rejuvenate UA Formulas promote: ➕Mitochondrial Health and Function ➕Cellular Health ➕Positive Impacts on Bio-Markers and Hallmarks of Aging ➕Metabolic Health ➕Diminished Oxidative Stress Plus:    ⚡NAC + Glycine Supports & Replenishes Optimal Glutathione Levels ⚡Rejuvenate UA Improves Skin Health, Immune Function and Supports Healthy Inflammatory and Neuroinflammatory Processes!   Add our Senolytic Formula and Experience Additional Potent and Precise Healthy Aging Benefits Including: ➕Systemic Cell Repair and Rejuvenation Throughout the Body ➕Inflammation Reduction using Natural Senolytic Compounds ➕Select Targeting and Reduction of Senescent Cells, SASP Factors and Senescence-Associated-β Galactosidase ➕Both Heart Health and Cognitive Health Support ➕A Lower Risk of Age-Related Disease   These formulas work synergistically to create a truly comprehensive longevity stack.   🌟 🌟 🌟Our formulas are physician formulated and used in clinic 🌟 🌟 🌟   For a deeper dive into the individual products and how they work see below...   NAC + Glycine Promotes healthy aging/positively impacts hallmarks of aging Supports mitochondrial function Provides oxidative stress relief Restores glutathione levels Improves metabolic health Recent research has highlighted the potential benefits of NAC + Glycine, which combines N-acetylcysteine (NAC) and glycine, to include: Restoration of Healthy Gluathione Levels: Glutathione levels decline significantly with age, leading to increased oxidative stress and potentially contributing to various age-related health problems Improved Mitochondrial Function: NAC + Glycine supplementation has been shown to improve mitochondrial fatty acid oxidation and correct multiple aspects of mitochondrial dysfunction in older adults, including abnormalities in mitochondrial biogenesis, nutrient sensing, β-oxidation, electron transport chain function, ATP synthesis, and mitophagy Metabolic Health: Aging is also associated with the development of insulin resistance and metabolic dysfunction. NAC + Glycine supplementation has been shown to significantly improve insulin sensitivity and reduce insulin resistance in older adults, as measured by HOMA-IR Reduced Harmful Effects of Oxidative Stress: The ability of NAC + Glycine to improve glutathione status and reduce oxidative stress without inducing reductive stress is a key advantage over other antioxidant supplementation strategies A study from the Baylor College of Medicine suggests that the use of NAC + Glycine supplementation as a promising strategy for promoting healthy aging and improving multiple age-related health outcomes. By addressing key hallmarks of aging, such as glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, and physical decline, NAC + Glycine supplementation may help to prevent or mitigate various age-related diseases and extend healthspan.   Rejuvenate UA Informs youthful aging Promotes mitophagy Improves cellular health & bio-markers of aging Supports healthy immune function Accelerates exercise recovery Supports healthy inflammatory and neuroinflammatory processes Diminishes oxidative stress Improves skin health A unique blend of research backed ingredients including: Urolithin A Spermidine Ca-AKG ( Calcium Alpha-Ketoglutarate Monohydrate) MitoPrime™ (L-Ergothioneine) This combination was designed to mitigate aging and rejuvenate the body all the way down to the cellular level.* Urolithin A 500 mg Cellular Support: Promotes the function and activity of our mitochondria, the principal organelles responsible cellular energy production and critical for muscle energy metabolism, cell function and performance. By activating pivotal regulatory transcription factors involved in mitochondrial biogenesis, UA can assist in regulating the quantity and quality of mitochondria.  Longevity Enhancement: Promotes mitophagy, the autophagic removal of dysfunctional mitochondria, which is crucial for preventing age-related pathologies. UA activates the PINK1/parkin-dependent mitophagy pathway and other pathways, leading to the degradation of defective mitochondria. This process can mitigate age-related diseases, enhance mitochondrial health, and improve cellular function Neurological Support: May enhance mitochondrial function and improve motor and cognitive functions, supporting brain health. Additionally, it has displayed neuroprotective effects in neurodegenerative disease model studies, including reducing neuroinflammation, preventing the loss of dopaminergic neurons, decreasing α-synuclein aggregation, and inhibiting apoptosis. KEY BENEFITS: Supports cellular health, promotes mitophagy, reduces age-related diseases, offers neuroprotective effects, improves skin health, and more...* Spermidine 3 mg Cellular Support: Results from preclinical studies indicate spermidine supports DNA Stability, cellular growth, and apoptosis.  Longevity Enhancement: Results from preclinical studies indicate higher consumption of spermidine-rich foods correlates with reduced mortality and a life expectancy prolonged by 5 years.  Neurological Support: Results from preclinical studies indicate spermidine assists in the removal of toxic protein aggregates in cells; the cause of dementia and diseases like Parkinson's and Alzheimer's.  KEY BENEFITS: Replenishes depleted levels of Spermidine to inform youthful aging, and increases cellular and immune system health.* Ca-AKG (Calcium Alpha-Ketoglutarate Monohydrate) 1000 mg Antioxidant Support: Results from preclinical studies indicate that Ca-AKG protects against free radical damage related to aging processes and improves blood vessel elasticity in aging organisms.  Longevity Enhancement: Results from preclinical studies indicate Ca-AKG increases the health span of mice by 41% and reduces 31 different signs of age-related frailty. KEY BENEFITS: Decreases inflammation, increases cellular energy, improves training volume and power output in exercise, and improves bio-markers of aging.* MitoPrime™ (L-Ergothioneine) 10 mg Superior Antioxidant Activity: Results from preclinical studies indicate that supplemental L-ergothioneine is up to 30x better than glutathione, and significantly outperforms CoQ10 and Vitamin C.  Oxidative Stress Reduction: Results from preclinical studies indicate that supplemental L-ergothioneine can reduce oxidative stress, which protects mitochondrial function and DNA, and in turn protects against aging.  Restorative:  Results from preclinical studies indicate that supplemental L-ergothioneine can increase natural stores, which decline after age 18. Low levels are associated with suboptimal performance.  KEY BENEFITS: Improves cognitive function, and immune health. Diminishes oxidative stress and accelerates exercise recovery.* Learn more: Spermidine Ca-AKG(Calcium Alpha-Ketoglutarate Monohydrate)   Senolytic Formula Contains natural senolytic compounds that selectively target senescent cells Natural compounds help reduce inflammation and lower the risk of age-related diseases Supports systemic cell repair and rejuvenation throughout the body Designed with antioxidants to support heart health and enhance cognitive function Physician formulated and used in clinic Our formulation is created with with these ingredients to effectively target senescent cells: Fisetin is found in fruits like strawberries and apples. It has been shown to reduce oxidative stress and inflammation, enhance brain function, and extend lifespan in animal studies. Its senolytic activity helps clear senescent cells, potentially improving tissue function and resilience to age-related decline. Quercetin, present in foods like onions and berries, also exhibits strong anti-inflammatory and antioxidant properties. As a senolytic, quercetin can aid in removing senescent cells, as a result, it supports better cardiovascular health, reduces frailty, and potentially enhances overall longevity. Olive leaf extract (with 20% oleuropein) is rich in polyphenols, which possess strong antioxidant and anti-inflammatory properties. Oleuropein has been shown to protect cardiovascular health, support immune function, and potentially enhance metabolic health, contributing to overall vitality. Trans-resveratrol, a compound found in red grapes and berries, is renowned for its longevity-promoting effects. It activates certain pathways related to cellular health and stress resistance, enhancing cardiovascular health, reducing inflammation, and potentially extending lifespan by mimicking the effects of calorie restriction. Green tea extract, standardized to 50% EGCG and 90% polyphenols, is a powerhouse of antioxidants. EGCG (epigallocatechin gallate) is particularly effective in reducing oxidative stress, supporting brain health, and enhancing metabolic rate. Its polyphenols also contribute to anti-inflammatory effects and may help reduce the risk of chronic diseases. Cellular senescence is a natural part of the aging process and is often defined as a process by which a cell ages and permanently stops dividing but does not die. Instead of experiencing apoptosis (programed cell death), these cells remain, build up and begin to negatively affect surrounding cells via secreted pro-inflammatory factors including cytokines, immune modulators, growth factors and proteases. Senolytic compounds selectively target senescent cells. Wondering how you can help rid your body of senescent cells (aka zombie cells) that may build up due to stressors or simple aging? Curious if it is possible to prevent their formation? While many diet and lifestyle factors can reduce potential cell damage and enhance your own immune system’s natural "killer cell" activity, senolytic compounds are the most targeted and direct solution, and a vital component to a thriving body as you age.*