Cellular senescence is a natural part of the aging process and is often defined as a process by which a cell ages and permanently stops dividing but does not die. Instead of experiencing apoptosis (programed cell death), these cells remain, build up and begin to negatively affect surrounding cells via secreted pro-inflammatory factors including cytokines, immune modulators, growth factors and proteases. Senolytic compounds selectively target senescent cells.
Wondering how you can help rid your body of senescent cells (aka zombie cells) that may build up due to stressors or simple aging? Curious if it is possible to prevent their formation? While many diet and lifestyle factors can reduce potential cell damage and enhance your own immune system’s natural "killer cell" activity, senolytic compounds are the most targeted and direct solution, and a vital component to a thriving body as you age.*
Fisetin is found in fruits like strawberries and apples. It has been shown to reduce oxidative stress and inflammation, enhance brain function, and extend lifespan in animal studies. Its senolytic activity helps clear senescent cells, potentially improving tissue function and resilience to age-related decline.
Quercetin, present in foods like onions and berries, also exhibits strong anti-inflammatory and antioxidant properties. As a senolytic, quercetin can aid in removing senescent cells, as a result, it supports better cardiovascular health, reduces frailty, and potentially enhances overall longevity.
Olive leaf extract (with 20% oleuropein) is rich in polyphenols, which possess strong antioxidant and anti-inflammatory properties. Oleuropein has been shown to protect cardiovascular health, support immune function, and potentially enhance metabolic health, contributing to overall vitality.
Trans-resveratrol, a compound found in red grapes and berries, is renowned for its longevity-promoting effects. It activates certain pathways related to cellular health and stress resistance, enhancing cardiovascular health, reducing inflammation, and potentially extending lifespan by mimicking the effects of calorie restriction.
Green tea extract, standardized to 50% EGCG and 90% polyphenols, is a powerhouse of antioxidants. EGCG (epigallocatechin gallate) is particularly effective in reducing oxidative stress, supporting brain health, and enhancing metabolic rate. Its polyphenols also contribute to anti-inflammatory effects and may help reduce the risk of chronic diseases.
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