Alpha-GPC is one of the most bioavailable forms of choline, which can enhance levels of acetylcholine an important neurotransmitter in the brain. It is essential to get choline in the diet with primary sources being egg yolk and liver. The body can make choline although, during periods of high cognitive stress or cognitive demand, levels can quickly be depleted. It is also essential for pregnant and breastfeeding women. There are several genetic variants that can result in a significantly lower production of choline and supplementation can benefit.